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Panama City skyline from water.

16-night Panama Canal Cruise - Ocean To Ocean From Los Angeles, California

Puerto Vallarta

Aboard

Island Princess

From

Los Angeles, California

3 Sailings

Sep 20, 2026 - Apr 3, 2027

3 Sailings

Sep 20, 2026 - Apr 3, 2027

Published prices from

$1,399

per person*

taxes & fees included

San Diego skyline at dusk.

22-night Panama Canal & Pacific Coast Cruise From Vancouver, British Columbia

Puerto Vallarta

Aboard

Coral Princess

From

Vancouver, British Columbia

1 Sailing

Sep 23, 2026

1 Sailing

Sep 23, 2026

A golden sunset over the beach in Huatulco, Mexico, with footprints in the sand leading towards the shimmering ocean and a warm glow over the water.

16-night Panama Canal - Ocean To Ocean Cruise From Los Angeles, California

Puerto Vallarta

Aboard

Coral Princess

From

Los Angeles, California

1 Sailing

Sep 29, 2026

1 Sailing

Sep 29, 2026

Yellow kayak on sandy beach in Puerto Vallarta, Mexico.

16-night Panama Canal - Ocean To Ocean Cruise From Fort Lauderdale, Florida

Fuerte Amador (Panama City)

Aboard

Sapphire Princess

From

Fort Lauderdale, Florida

1 Sailing

Nov 6, 2026

1 Sailing

Nov 6, 2026

Hollywood sign on hills of Los Angeles.

16-night Panama Canal Cruise - Ocean To Ocean From Los Angeles, California

Puerto Vallarta

Aboard

Crown Princess

From

Los Angeles, California

1 Sailing

Dec 3, 2026

1 Sailing

Dec 3, 2026

Puntarenas, Costa Rica tropical landscape with palm trees and mountains.

16-night Panama Canal Cruise - Ocean To Ocean Holiday From Fort Lauderdale, Florida

Fuerte Amador (Panama City)

Aboard

Island Princess

From

Fort Lauderdale, Florida

1 Sailing

Dec 12, 2026

1 Sailing

Dec 12, 2026

A cruise ship navigating through the Gatun Locks of the Panama Canal, an important navigational route and popular tourist destination.

16-night Panama Canal Cruise - Ocean To Ocean Holiday From Los Angeles, California

Puerto Vallarta

Aboard

Island Princess

From

Los Angeles, California

1 Sailing

Dec 28, 2026

1 Sailing

Dec 28, 2026

Boats on a canal in Fort Lauderdale.

23-night 2027 World Cruise Segment: Panama Canal - Ocean To Ocean From Fort Lauderdale, Florida

Cartagena (Colombia)

Fuerte Amador (Panama City)

Aboard

Coral Princess

From

Fort Lauderdale, Florida

1 Sailing

Jan 6, 2027

1 Sailing

Jan 6, 2027

A historic brick structure with multiple arches and a fountain visible through the center, in a sunny plaza in Chiapas, Mexico.

15-night 2027 World Cruise Segment: Panama Canal - Ocean To Ocean From Fort Lauderdale, Florida

Cartagena (Colombia)

Fuerte Amador (Panama City)

Aboard

Coral Princess

From

Fort Lauderdale, Florida

1 Sailing

Jan 6, 2027

1 Sailing

Jan 6, 2027

A close-up of a majestic bald eagle perched on a wooden post in a forest near Sitka, Alaska, with its distinctive white head and yellow beak visible.

129-night 2027 World Cruise Grand Circle Pacific - Ft. Lauderdale To Los Angeles From Fort Lauderdale, Florida

Cartagena (Colombia)

Fuerte Amador (Panama City)

Aboard

Coral Princess

From

Fort Lauderdale, Florida

1 Sailing

Jan 6, 2027

1 Sailing

Jan 6, 2027

A golden sunset over the beach in Huatulco, Mexico, with footprints in the sand leading towards the shimmering ocean and a warm glow over the water.

16-night Panama Canal Cruise - Ocean To Ocean From Fort Lauderdale, Florida

Fuerte Amador (Panama City)

Aboard

Island Princess

From

Fort Lauderdale, Florida

4 Sailings

Jan 13 - Apr 19, 2027

4 Sailings

Jan 13 - Apr 19, 2027

A cruise ship navigating through the Gatun Locks of the Panama Canal, an important navigational route and popular tourist destination.

16-night Panama Canal Cruise - Ocean To Ocean From San Diego, California

Puerto Vallarta

Aboard

Island Princess

From

San Diego, California

1 Sailing

Jan 29, 2027

1 Sailing

Jan 29, 2027

Puntarenas, Costa Rica tropical landscape with palm trees and mountains.

16-night Panama Canal Cruise - Ocean To Ocean From Fort Lauderdale, Florida

Cartagena (Colombia)

Fuerte Amador (Panama City)

Aboard

Crown Princess

From

Fort Lauderdale, Florida

1 Sailing

Apr 4, 2027

1 Sailing

Apr 4, 2027

Published prices from

$1,399

per person*

taxes & fees included

Hollywood sign on hills of Los Angeles.

16-night Panama Canal - Ocean To Ocean Holiday Cruise From Fort Lauderdale, Florida

Fuerte Amador (Panama City)

Aboard

Island Princess

From

Fort Lauderdale, Florida

1 Sailing

Dec 13, 2027

1 Sailing

Dec 13, 2027

Panama City skyline from water.

16-night Panama Canal - Ocean To Ocean Cruise From Fort Lauderdale, Florida

Cartagena (Colombia)

Fuerte Amador (Panama City)

Aboard

Island Princess

From

Fort Lauderdale, Florida

4 Sailings

Jan 14 - Apr 19, 2028

4 Sailings

Jan 14 - Apr 19, 2028

Published prices from

$3,394

per person*

taxes & fees included

Hollywood sign on hills of Los Angeles.

16-night Panama Canal - Ocean To Ocean Cruise From Fort Lauderdale, Florida

Fuerte Amador (Panama City)

Aboard

Emerald Princess

From

Fort Lauderdale, Florida

1 Sailing

Apr 22, 2028

1 Sailing

Apr 22, 2028

*Rates and offers are per person, in US Dollars, based on double occupancy, capacity controlled, subject to availability and confirmation, and may change without notice. Government taxes and fees are included. Rates and offers are available for select dates and categories only. Additional restrictions may apply. Call 1-800-377-9383 for full terms and conditions.